北京時間12月17日淩晨 ，意大尤文意大利杯第二輪最後兩場比賽結束 ，利杯萊切客場2-0戰勝斯佩齊亞 、对阵桑普多利亞主場2-1戰勝都靈 。签运区至此本賽季意大利杯16強全部產生，不错八分之一決賽的米兰對陣也已經出爐。
尤文圖斯 、国米亞特蘭大 、同半國際米蘭 、意大尤文AC米蘭、利杯羅馬 、对阵拉齊奧 、签运区那不勒斯 、不错薩索洛作為種子隊 ，米兰直接晉級本賽季意大利杯16強 ，国米而其他球隊則通過兩輪比賽決出另外8個晉級名額 。意大利杯八分之一決賽為主客場兩回合，比賽時間為2022年1月12日和19日 。16強中隻有萊切是意乙球隊 ，其餘均為意甲球隊 。
如果種子隊都能晉級 ，那麽四分之一決賽將是尤文對薩索洛 、那不勒斯對亞特蘭大、米蘭對拉齊奧 、羅馬對國米 。尤文 、薩索洛 、那不勒斯 、亞特蘭大被分在上半區 ，米蘭、拉齊奧 、羅馬 、國米被分在下半區 ，兩個半區分別競爭一個決賽名額 。
意大利杯八分之一決賽對陣：
上半區 ：
尤文圖斯 VS 桑普多利亞
薩索洛 VS 卡利亞裏
那不勒斯 VS 佛羅倫薩
亞特蘭大 VS 威尼斯
下半區 ：
AC米蘭 VS 熱那亞
拉齊奧 VS 烏迪內斯
羅馬 VS 萊切
國際米蘭 VS 恩波利
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